Integrative Cancer Biology Program Datasets

By Jonathan Bistline1, Michael Reich1

1. Broad Institute

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Abstract

The NCI-ICBP promotes an integrative/systems approach to the study of cancer biology. The Program encourages scientists to study cancer as a complex biological system. Information gained from these studies are used to build reliable and testable predictive computation models of cancer processes that can be used to generate interventions for preventing, detecting and treating cancer.  Datasets from the various projects are made available here.

Cite this work

Researchers should cite this work as follows:

  • Jonathan Bistline; Michael Reich (2016), "Integrative Cancer Biology Program Datasets," https://ncihub.org/resources/1736.

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In This Series

  1. Integrated analysis of breast cancer cell lines reveals unique signaling pathways

    16 Sep 2014 | Publications | Contributor(s): Laura M Heiser, Nicholas J Wang, Carolyn L Talcott, Keith R Laderoute, Merrill Knapp, Yinghui Guan, Zhi Hu, Safiyyah Ziyad, Barbara L Weber, Sylvie Laquerre, Jeffrey R Jackson, Richard F Wooster, Wen Lin Kuo, Joe W Gray, Paul T Spellman

    AbstractBackgroundCancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EgfR-MAPK pathway is common in breast cancer, though the manner in which...

  2. Baylor Residual breast cancer

    13 Nov 2014 | Downloads | Contributor(s): Creighton C, Lewis M, Chang J, Jonathan Bistline

    Residual breast cancers after conventional therapy display mesenchymal as tumor-initiating features.  There are four (4) files included in this study: Sample Annotation (combined_sample_annotation.txt) Gene expression data from CD44+/CD24- cells sorted by flow cytometry (GSE7513.gct) Human...

  3. LBL Expanded ICBP43 integrative genomic data

    13 Nov 2014 | Downloads | Contributor(s): Joe Gray, Jonathan Bistline

    There are six (6) datasets in this study: Reverse protein lysate array (JWGray_BCCL_RPPA_timecourse_Lapatinib_v1-1.txt)  Reverse protein lysate array readme (JWGray_BCCL_RPPA_timecourse_Lapatinib_v1-1_readme.txt) Affymetrix SNP data (icbp43_affy_snp.zip) Segmented copy number data...

  4. LBL ICBP50 integrative genomic data

    13 Nov 2014 | Downloads | Contributor(s): Joe Gray, Jonathan Bistline

    From Joe Gray, Lawrence Berkeley National Laboratory.  There are seventeen (17) files in this study: Affymetrix U133A gene expression data (icbp_u133a.gct) Affymetrix U133A gene expression data (ICBP_U133a.zip) Affymetrix splice junction exon-exon data (ICBP_Junction.zip) Affymetrix...

  5. OSU/IU ICBP50 integrative genomic data

    13 Nov 2014 | Downloads | Contributor(s): Yunlong Liu, Jonathan Bistline

    Multi-domain assays of genome-wide DNA methylation and histone modification patterns in MCF7 and OHT drug resistant cells.  Data are produced at LBNL and the OSU, provided from Indiana University School of Medicine (Yunlong Liu).  There are eighteen (18) datasets in this study:...

  6. OSU ICBP45 integrative genomic data

    13 Nov 2014 | Downloads | Contributor(s): Jonathan Bistline

    There are forty one (41) datasets in this study: 1-40. MBDCap-seq data (100727_s_3_sorted.tdf to 100910_s_4_sorted.tdf) 41. Sample Annotation (osu_icbp45_sample_annotation.txt) These datasets have been exported from the Broad Institute's ICBP Data & Analysis Portal.

  7. Tufts Gene Expression Data for Low Dose Radiation Experiments

    13 Nov 2014 | Downloads | Contributor(s): Lynn Hlatky, Edward Rietman, Jonathan Bistline

    Expression signatures from low dose radiation exposure of various types of tissues. There are eight (8) files in this study: 1-7. Gene expression of cell lines exposed to low-dose radiation (5727049056.zip to 7196780010.zip) 8. Sample Annotation (ICBP_Data_Upload_Samples.xlsx)...

  8. Vanderbilt Single-cell motility data

    13 Nov 2014 | Downloads | Contributor(s): Vito Quaranta, Shawn Garbett, Jonathan Bistline

    All epithelial-derived cell lines (MCF10A, AT1, and CA1d) were plated on laminin-332, and incubated under either "mild" or "harsh" microenvironmental conditions (full tissue culture media vs. deprived media (-fetal bovine serum, -EGF), respectively). Single-cell motility was...

  9. Vanderbilt PC9 cell line exposed to varying concentrations of erlotinib

    13 Nov 2014 | Downloads | Contributor(s): Vito Quaranta, Shawn Garbett, Jonathan Bistline

    Histone H2B labeled PC9 NSCLC cell line exposed to varying concentrations of erlotinib.  There are twenty-five (25) files in this study: 1-24. Cell Motility Movies (*.mov) 25. Sample Annotation (2011-06-13_PC9_erlot_plate_map.txt) These datasets have been exported from the Broad...