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NCL Method STE-1.1

By Barry Neun, Marina Dobrovolskaia

Detection and Quantification of Gram Negative Bacterial Endotoxin Contamination in Nanoparticle Formulations Using the End Point Chromogenic LAL Assay

Listed in Datasets | publication by group NCL Protocols

Version 1.0 - published on 14 Jun 2021 doi:10.17917/5WSQ-7X78 - cite this

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This document describes a protocol for a quantitative detection of Gram negative bacterial endotoxin in nanoparticle preparations using an end-point Limulus Amebocyte Lysate (LAL) assay. The protocol is based on the QCL-1000 kit manufactured by Lonza Corporation [1] and the USP standard 85 "Bacterial endotoxin test" [2]. 

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