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NCL Method ITA-2.1

By Jamie Rodriguez, Barry Neun, Anna Ilinskaya, Marina Dobrovolskaia

Analysis of Platelet Aggregation By Cell Counting

Listed in Datasets | publication by group NCL Protocols

Version 2.0b - published on 24 Jul 2020 doi:10.17917/0165-RC67 - cite this

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Description

This document describes a procedure for analysis of platelet aggregation [1-6]. Platelets are small (~2 mm) anuclear cells obtained by fragmentation of megakaryocytes. Platelets, also known as thrombocytes, play a key role in hemostasis. Abnormal platelet counts and function may lead to either bleeding or thrombosis. Assessing nanoparticle effects on human platelets in vitro allows for quick screening of their potential anticoagulant or thrombogenic properties mediated by direct effects on platelets.

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