IFNγ has variable effects on expression of MHC Class I and ICAM-1 in pediatric cancers which alter sensitivity to NK cell mediated lysis
01 Jun 2016 | Contributor(s): Arianexys Aquino-Lopez, Vladimir Senyukov, Gabrielle Romain, Navin Varadarajan, Dean A. Lee
Interferon-γ (IFNγ), a cytokine secreted by effector lymphocytes upon activation, is known to cause upregulation of MHC class I in tumor cells, which has been associated with natural killer (NK) cell inhibition. NK cells are very heterogeneous with respect to receptor expression and...