Paul Macklin is a mathematician, Associate Professor, and Director of Undergraduate studies in the recently-established Department of Intelligent Systems Engineering at Indiana University. His lab works with teams of biologists, modelers, and clinicians to develop and validate sophisticated computer models of multicellular systems, with a focus on cancer, tissue engineering, and synthetic systems. To drive this work, his lab develops open source tools for 3-D multicellular systems biology, including BioFVM (multi-substrate diffusive transport; DOI: 10.1093/bioinformatics/btv730) and PhysiCell (off-lattice agent-based modeling; DOI: 10.1371/journal.pcbi.1005991). His lab also develops techniques to ease the use and increase the utility of agent-based modeling, including high-throughput investigations on HPC resources (DOI: 10.1186/s12859-018-2510-x), cloud-hosted interactive simulators (e.g., https://nanohub.org/tools/pc4cancerimmune), ad hoc small team crowdsourcing, and machine learning-driven model exploration.
An example of these modeling systems can be seen in this 3-D model of tumor-immune contact interactions: