HTT update Current
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| 1 | [MainPage Wiki Main Page] | |||
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| 2 | ||||
| 3 | [HTTupdates Previous Updates] | |||
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| 6 | + | [https://didsr.github.io/HTT.home/ Due to the coming shutdown of the NCIhub, we have a new site for updates.]
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| 8 | ||||
| 9 | We are pleased to announce some recent accomplishments of the High-throughput truthing project (HTT). | |||
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| 11 | A list of all previous updates can be found [HTTupdates on this page]. Our publications and presentations are organized [https://www.zotero.org/groups/4384613/eedap_studies_presentations_publications_and_studies/library in this Zotero library]. Our data is being shared [https://github.com/DIDSR/HTT in this GitHub repository.] | |||
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| 13 | The HTT project’s '''objective''' is to create a validation dataset fit for a regulatory purpose. Pursuing this objective is expected to inform regulatory frameworks and be instructive to others to develop their own validation datasets. For more detailed information about the project and/or to register as a pathologist-data-collector, please visit [https://ncihub.org/groups/eedapstudies/]. | |||
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| 15 | The HTT project has been accepted as a project of the Truthing and Validation Workgroup of '''PIcc'''. | |||
| 16 | * PIcc is The Pathology Innovation Collaborative Community. | |||
| 17 | * PIcc is pronounced "Pie" CC. | |||
| 18 | * [https://www.digitalpathologyalliance.org/truthing-validation Link to the Truthing and Validation workgroup.] | |||
| 19 | * [https://www.fda.gov/about-fda/cdrh-strategic-priorities-and-updates/collaborative-communities-addressing-health-care-challenges-together Link to the FDA Collaborative Communities Program.] | |||
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| 21 | The HTT project was also accepted as a project of the W.H.O. International Collaboration for Cancer Classification and Research (IC3R). | |||
| 22 | * The IC3R project is named PADEA (Pathologist Annotation Datasets for Evaluating Algorithms) to allow the effort to grow to other applications beyond TILs evaluation. | |||
| 23 | * [https://ic3r.iarc.who.int/projects/ Link to IC3R "Projects" page.] | |||
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| 25 | To contact us with any questions or join our efforts: [HTTContacts Contact Us HERE] | |||
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| 27 | ---- | |||
| 28 | =Updates= | |||
| 29 | ||||
| 30 | ==== October 2022 ==== | |||
| 31 | * Brandon Gallas presented to the FDA Oncology Center of Excellence | |||
| 32 | * "Developing a dataset to validate computational models that analyze digital pathology images to assess tumor-infiltrating lymphocytes (TILs) in breast cancer" | |||
| 33 | * [https://ncihub.org/groups/eedapstudies/wiki/Presentation2022:FDAOCEWebinarValidatingModelsinDigitalPathology:OverviewofHTTProjectGallas Link to Recording and Slides] | |||
| 34 | ||||
| 35 | ==== September 2022 ==== | |||
| 36 | * Personal Celebrations! Project managers Victor Garcia, and Kate Elfer celebrated their weddings to their significant others! | |||
| 37 | ||||
| 38 | ==== August 2022 ==== | |||
| 39 | * Slides for our pivotal study have been received from Emory University and Stony Brook University and scanned with an Aperio AT2 DX (FDA-qualified WSI scanner) | |||
| 40 | * Brandon Gallas presented to the Pathology Innovation Collaborative Community a Webinar on "ROC and MRMC Tutorials" | |||
| 41 | * [https://ncihub.org/groups/eedapstudies/wiki/Presentation2022:PathologyInnovationCollaborativeCommunityWebinarROCandMRMCTutorialsGallas Link to Recordings, Slides, and Abstract] | |||
| 42 | ||||
| 43 | * Brandon Gallas and Si Wen presented their work at the Joint Statistical Meeting: | |||
| 44 | * Brandon Gallas, "Exploring Pathologist-Pathologist Agreement as a Baseline for Algorithm-Pathologist Agreement" | |||
| 45 | * Si Wen, "Limits of Agreement for an MRMC Study" | |||
| 46 | ||||
| 47 | ==== July 2022 ==== | |||
| 48 | ||||
| 49 | * '''Info Sharing''': One day, the public health emergency will be declared over. Here is guidance on what happens to devices that fall within pandemic enforcement policies, like WSI scanners: [https://www.fda.gov/regulatory-information/search-fda-guidance-documents/transition-plan-medical-devices-fall-within-enforcement-policies-issued-during-coronavirus-disease LINK] | |||
| 50 | ||||
| 51 | * Open-Position: ORISE Fellow | |||
| 52 | * Victor Garcia, MD, is transitioning into an FDA/CDRH/DIDSR full-time staff fellow | |||
| 53 | * We therefore have an open ORISE Fellow position for the next year (starting 01 October 2022): Statistics and Informatics Support the Assessment of Artificial Intelligence and Machine Learning | |||
| 54 | * Actively recruiting now - please distribute! [[File(jobDescriptionDigitalPathologyAIML-20220617-2_1.pdf)]] | |||
| 55 | ||||
| 56 | * '''Needed:''' We are looking for an FDA-cleared Scanner. We are targeting the the Aperio AT2 DX because it has a format that is open enough to be supported by several software tools and platforms. | |||
| 57 | * One batch of pivotal study slides are in our hands! | |||
| 58 | ||||
| 59 | * Upcoming Presentations: American Statistical Association's Joint Statistical Meeting | |||
| 60 | * Session: Assessing Agreement and Reader Reliability in Medical Imaging Analysis (organized by Si Wen) | |||
| 61 | * August 7th, 2022 in Washington DC | |||
| 62 | * [https://ww2.amstat.org/meetings/jsm/2022/onlineprogram/ActivityDetails.cfm?SessionID=221988 Link to Session Info] | |||
| 63 | * Brandon will present "Exploring Pathologist-Pathologist Agreement as a Baseline for Algorithm-Pathologist Agreement" | |||
| 64 | * Si will present "Limits of Agreement for an MRMC Study" | |||
| 65 | * | |||
| 66 | * We hope to schedule a redux of the session to be hosted by PIcc. | |||
| 67 | * Published: Hongfei Du, Si Wen, Yufei Guo, Fang Jin, and Brandon D. Gallas, “Single reader between-cases AUC estimator with nested data,” Stat Methods Med Res, p. 9622802221111540, Jul. 2022, doi: [https://journals.sagepub.com/doi/10.1177/09622802221111539 10.1177/09622802221111539]. | |||
| 68 | ||||
| 69 | ==== June 2022 ==== | |||
| 70 | * Re-Introduction: Phoebe Qian, ORISE Intern | |||
| 71 | *[https://ncihub.org/groups/httleadership/wiki/AdminCollaboratorPhoebeQian Please see Phoebe's Admin page] | |||
| 72 | * Phoebe is rising high school senior returning for her second summer with us! | |||
| 73 | * Phoebe is hunting for colleges for Fall 2023 with a focus on computer science | |||