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HTT update 20201023

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HTT data-collection relaunch and project update. Help Needed.

Update: October 23, 2020

Dear all,

We are pleased to announce some recent accomplishments of the High-throughput truthing project (HTT) and request your assistance to maintain progress (HELP!).

The HTT project’s objective is to create a validation dataset fit for a regulatory purpose. Pursuing this objective is expected to inform regulatory frameworks and be instructive to others to develop their own validation datasets. For more detailed information about the project and/or to register as a pathologist-data-collector, please visit https://ncihub.org/groups/eedapstudies/.

HELP! We need more pathologist annotations and physical slides to complete our pilot study.

Once the pandemic subsides, we are also hoping to recruit host sites for collecting microscope-mode data using the eeDAP platform (LINK to eeDAP manuscript, Link to eeDAP GitHub repo).

To contact us with any questions or join our efforts: Contact Us HERE

Accomplishments

  • Manuscript submitted and in pre-publication with the first results to the Journal of Pathology Informatics!
    • Poster presentation: “A Pathologist-Annotated Dataset for Validating AI/ML: A Project Description and Pilot Study”, Link
    • Pre-Publication Link: https://arxiv.org/abs/2010.06995
  • We have developed pilot data and data aggregation pipelines.
  • We have made progress on the development of statistical analysis plans. For a related presentation, click HERE.
  • We have submitted an inquiry to the FDA Medical Device Development Tool program, received feedback, and are drafting our response and full MDDT qualification plan.
  • We have developed RCA (Research Collaboration Agreement- templates, for the template, click HERE. (https://ncihub.org/groups/eedapstudies/wiki/HighThroughputTruthingYear3)
  • We have submitted an internal funding proposal to the FDA Office of Women’s Health.
  • FDA has recruited Katherine Elfer, a NCI-FDA Cancer Prevention Fellowship Program / Interagency Oncology Task Force fellow, to work on this project.
  • Thanks for all your support with spreading the word about what we do! For more details or questions, contact Katherine Elfer (Katherine.Elfer@fda.hhs.gov) and Brandon Gallas (Brandon.Gallas@fda.hhs.gov).

    The HTT Leadership Team,

    Brandon Gallas, FDA; Project Lead

    Katherine Elfer, FDA, Project Coordinator

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