HTT Data Collection Training Pilot Study
- Version 36
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- Version 37
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| 1 | [MainPage Wiki Main Page] | |||
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| 3 | = This Page Is No Longer In Use: Archived = | |||
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| 10 | ==HTT Data Collection Training== | |||
| 11 | ||||
| 12 | ===Overview of the Data Collection Tasks:=== | |||
| 13 | You will be presented pre-selected regions of interest (ROIs) digitally or on a microscope | |||
| 14 | For each ROI, please complete three tasks: | |||
| 15 | 1) '''__Label the ROI__''': Please label each ROI in order to determine whether it can be evaluated for sTILs. | |||
| 16 | * __Intra-tumoral stroma__: Stroma within the limits of cancer (NOT intro-epithelial TILs). | |||
| 17 | * __Invasive Margin__: Typically 1 mm, contains an edge of malignant cell nests. | |||
| 18 | * __Tumor with NO intervening stroma__: Densely packed tumor with no stroma, regardless of immune infiltrate | |||
| 19 | * __Other regions__: Necrosis, fibrosis, or other areas of granulocytic infiltrate. | |||
| 20 | 2) '''__Record % of Tumor-Associated Stroma__''': You will be prompted to record the estimated density percent of tumor-associated stroma. The percent tumor-associated stroma is a number from 0-100, and training for this evaluation is below. [[BR]] [[BR]] | |||
| 21 | 3) '''__Record % of sTIL density__''': You will be prompted to record the estimated density percent tumor-associated stromal | |||
| 22 | TIL density (sTIL density). The percent sTIL density is a number from 0-100, and training for this evaluation is below. | |||
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| 26 | These materials were created by the [https://www.tilsinbreastcancer.org/ International Immuno-Oncology Working Group (TILs in breast cancer).] | |||
| 27 | ||||
| 28 | ===REQUIRED Tasks=== | |||
| 29 | * [https://ncihub.org/groups/eedapstudies/wiki/HTTtrainingVideoClinical/ Watch the clinical TILs evaluation training video (8 minutes).] | |||
| 30 | * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267863/ TILs evaluation manuscript] | |||
| 31 | * R. Salgado et al., “The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014,” ''Ann. Oncol.'', '''vol. 26''', no. 2, pp. 259–271, Feb. 2015, doi: [https://doi.org/10.1093/annonc/mdu450 10.1093/annonc/mdu450]. | |||
| 32 | + | * These materials were created by the [https://www.tilsinbreastcancer.org/ TILs in breast cancer working group].
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| 34 | * [https://ncihub.org/groups/eedapstudies/wiki/HTTStartDataCollection/File:HTT_IRBinformedConsent.pdf Review the Informed Consent form] | |||
| 35 | * The Informed Consent provides information about the study purpose, what you will be asked to do as a participant, and the potential risks and benefits. Proceeding with the study acknowledges consent to participate. You are encouraged to ask questions before deciding to participate, or at any time during the course of the study. | |||
| 36 | ||||
| 37 | ===More Training and Information=== | |||
| 38 | ===='''Learn how to estimate the density of sTILs'''==== | |||
| 39 | * [https://ncihub.org/groups/eedapstudies/wiki/HTTtrainingClinical/File:calibrationCheatSheet.pdf Review and save the "Calibration Cheat Sheet"] | |||
| 40 | * [https://youtu.be/9U8D2RFILBk Optional TILs evaluation training video with more examples] (13 minutes) | |||
| 41 | * Slides from the optional training video: [[File(TutorialWebsiteAdapted29012020.pdf)]] | |||
| 42 | ||||
| 43 | + | ====Learn about the study====
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| 44 | ||||
| 45 | - | + | '''The Study:''' [[File(dataCollectionTutorialHTT.pdf)]] – This tutorial outlines the project, and provides a demonstration of your tasks for all three data collection platforms.
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| 46 | * [https://youtu.be/ateLnVU312g Training Video for caMicroscope] (5 min) | |||
| 47 | * [https://youtu.be/isAdNFWZK3M Training Video for Path Presenter] (5 min) | |||
| 48 | ||||
| 49 | ===='''Begin Data Collection!'''==== | |||
| 50 | [HTTStartDataCollection Click HERE to move to the launch point for data collection.] | |||
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| 52 | '''If you have any questions: [HTTContacts Contact Us]''' | |||