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Intratumoral heterogeneity of radioisotopic FDG and pathology H&E images using earth mover distance and radiomics in TNBC PDX

Sudipta Roy, Timothy Whitehead, Amanda Klaas, Kooresh Shoghi

Department of Radiology, Washington University School of Medicine,

Saint Louis, MO, USA

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Precision Imaging of Response to Therapy in Co-Clinical FDGPET Imaging of Triple Negative Breast Cancer (TNBC) Patient- Derived Tumor Xenografts (PDX)

Madhusudan A. Savaikar1, Timothy Whitehead1, Sudipta Roy1, Lori Strong1, Nicole Fettig1, Tina Prmeau2, Jingqin Luo3, Shunqiang Li2, Richard L. Wahl1, Kooresh I. Shoghi1,4
 

1Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA
2Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, USA
3Department of Surgery, Washington University School of Medicine, St. Louis, USA
4Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA

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Deep Learning based Segmentation of Tumors from TNBC PDX MR Images and Sensitivity of Radiomics Features to Segmentation Probability Boundaries

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Integrating Omics and Quantitative Imaging Data in Co-Clinical Trials: ePAD_Stanford_Dr. Rubin

Integrating Omics and Quantitative Imaging Data in Co-Clinical Trials: ePAD Platform for Extracting Image Features

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PDX Portal_BCM_HeidiDowst

PDXportal as an Integration Tool for Image Features Indicative of Treatment Response in PDX Models and Patients as a Predictor of Patient Outcomes

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PET Imaging of Glutamine Metabolism in a Colorectal Cancer Co-Clinical Trial

Allison S. Cohen*,  Adria Payne, Trey Claus, Ling Geng, Gary T. Smith, Gregory D. Ayers, Jennifer G. Whisenant, Todd E. Peterson, Kristen K. Ciombor, Dana Cardin, Cathy Eng, Laura Goff, Satya Das, Robert J. Coffey, Jordan D. Berlin, and H. Charles Manning

Vanderbilt University Medical Center, Nashville, TN 37232

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Validation of quantitative imaging biomarkers with histopathological analyses

Emma Furth, MD*, Yong Fan, PhD, Steven Pickup, PhD, Thomas Karasic, MD, Mark Rosen, MD, PhD, Peter O’Dwyer, MD, Rong Zhou, PhD

Departments of Pathology, Hematology-Oncology and Radiology, University of Pennsylvania, Philadelphia, PA 19104

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Reproducibility of Diffusion-Weighted Radial vs. Conventional EPI Protocols in GEM Model of Pancreatic Cancer

Hee Kwon Song, PhD, Jianbo Cao, PhD, Stephen Pickup, PhD, Hanwen Yang, Victor Castillo, Cynthia Clendenin, DVM, Jinbo Chen, PhD and Rong Zhou, PhD
Department of Radiology University of Pennsylvania, Philadelphia, PA 19104

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Fast magnetic resonance imaging using adaptive convolutional neural networks for k-space data interpolation

*Yong Fan, PhD, Steven Pickup, PhD, Hee Kwon Song, PhD, Mark Rosen, MD, PhD, Rong Zhou, PhD
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104

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Radial Sampling and KWIC Reconstruction Reduce Motion Artifacts for DCE-MRI of Mouse Pancreatic Cancer

Stephen Pickup*, PhD, Hee Kwon Song, PhD, Jianbo Cao, PhD and Rong Zhou, PhD
Department of Radiology University of Pennsylvania, Philadelphia, PA 19104  

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How the choice of PK model and AIF affect DCE-MRI detection of pancreatic cancer responses to stroma-directed drug?

Jianbo Cao, PhD, Stephen Pickup, PhD, Hee Kwon Song, PhD, Jinbo Chen, PhD, Peter O’Dwyer, MD, Mark Rosen, MD, PhD and *Rong Zhou, PhD

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Development of MRI Bone Marrow Biomarkers for Assessment of Treatment Response Using a 7T Cryoprobe - University of Michigan

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MRI Assessment of a Mouse Model of Myelofibrosis - University of Michigan

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Automatic Segmentation with Radiomic Analysis of Sarcoma in Mice

Matt Holbrook, Stephanie Blocker, Yvonne Mowery, Alexandra Badea, Yi Qi, Eric Xu, David Kirsch, Al Johnson, Cristian Badea

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Vanderbilt Team: Caroline Nebhan Poster

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Quantitative imaging for personalized mathematical models in oncology. David A. Hormuth II, Angela M. Jarrett, et al., UT Austin

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Precision and prediction of response to docetaxel/carboplatin therapy using machine-learning optimized radiomic features in preclinical FDG-PET imaging of TNBC Patient-Derived Tumor Xenografts

Sudipta Roy, Timothy Whitehead, Madhusudan Savaikar, Nicole Fettig, Tina Primeau, Shunqiang Li, Kooresh Shoghi

Department of Radiology, Washington University School of Medicine, Saint Louis, MO-63110, USA

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Decoding heterogeneous tumor MR signals: MR histology and cytometric feature mapping connects 2D pathology and in vivo MRI of sarcomas (Poster #7)

Stephanie Blocker, James Cook, Yvonne Mowery, Jeffrey Everitt, Yi Qi, Cristian Badea, David Kirsch, G A Johnson

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Rutul Patel Poster (CIRP Annual Meeting)

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Biopsy Clips: Challenges to Quantitative Breast MRI (Poster #19)

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R25 YES

The R25 Youth Enjoy Science funding opportunity announcement has expired. The YES FOA is currently being updated for reissuance. We are aiming for publication in May or June in time for a September submission date. 

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Diversity Supplements

NCI Diversity Supplements support the research training of students, post-baccalaureate and post-Masters individuals, postdoctoral fellows, and faculty investigators.

NCI Diversity Supplements Application Receipt Dates are October 1 – December 1 and February 1 – April 30 (for FY 2021).

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Youth Enjoy Science Program at the Case Comprehensive Cancer Center: Increasing Engagement and Opportunity for Underrepresented Minority Students

 The Youth Enjoy Science (YES) Program at the Case Comprehensive Cancer Center is a National Cancer Institute (NCI) R25- funded training grant, designed to increase the pipeline of underrepresented minor­ity (URM) students entering college and pursuing biomedical research and health care careers in the Cleveland Metropolitan and surrounding school districts. The three components of the program include: Learn to Beat Cancer, engaging middle school students and their families; Research to Beat Cancer, designed for high school students and college undergraduates; and Teach to Beat Cancer, focused on enhancing science, technology, engineering, and mathemat­ics (STEM) teaching capacity among high school teachers. This study focuses on Research to Beat Cancer, which, in 2018 enrolled 36 URM students as paid sum­mer scholars. Students were assigned to a faculty mentor, were taught laboratory safety, responsible conduct of research and the scientific method, and then immersed in full-time laboratory cancer research during an eight-week period. Twice each week, students participated in Lunch and Learn Seminars where faculty members provided combined motivational and scientific guid­ance lectures. In a capstone poster session at the end of the program, students pre­sented their research to peers, medical and graduate students, family members, faculty, community members and leaders. Students’ perceptions of the program were reported using descriptive statistics and qualitative thematic analyses. Twenty-four of the 2018 YES students (67%) and 19 (53%) mentors completed the online post-program survey. Opportunity was a major qualitative theme from student and mentor responses. Future research will investigate the long-term im­pacts of YES, including college enrollment. Ethn Dis. 2020;30(1):15-24; doi:10.18865/ ed.30.1.15

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The Cancer Crisis in Appalachia: Kentucky Students TAke ACTION

Dr. Nathan Vanderford and his team at the University of Kentucky, is publishing a book with their high school YES participants about how the high cancer rates in Appalachian Kentucky impact their families and communities. 

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